PREPARATION AND OPTIMISATIONOF PALM-BASED LIPID NANOPARTICLES LOADED WITH GRISEOFULVIN
نویسندگان
چکیده مقاله:
Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by hot homogenisation and a solvent-free method. The optimum griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, such as high pressure homogenisation (HPH) parameters, lipid and surfactant screening and selection of suitable lipid to surfactant ratios; followed by photon correlation study. A HPLC method has also been validated for the drug loading capacity study. The optimum HPH parameter was determined to be 1500 bar with 5 cycles and among the lipid based materials; Lipid C (triglycerides) was selected for the preparation of lipid nanoparticles. Tween 80 was chosenfrom the Tween series surfactantsfor its highest saturated solubility of griseofulvinat 53.1 ± 2.16 µg/mL. The optimum formulation of the griseofulvin loaded lipid demonstrated nano range particle size (179.8 nm) withintermediate distribution index (PDI) of 0.306, zeta potential of -27.9 mV and drug loading of 0.77%. The formulation was stable upon storage for 1 month at room temperature (25ºC) and higher temperature (45ºC) with consistent drug loading capacity.
منابع مشابه
Preparation and Optimization OF Palm-Based Lipid Nanoparticles Loaded with Griseofulvin
Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. The griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, by altering the high pressure homogenisation (HPH) parameters, screening on palm-based lipids and Tween series surfactants and selection of lipid to surfactant ratios. A HPLC method has be...
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عنوان ژورنال
دوره 16 شماره 2
صفحات 451- 461
تاریخ انتشار 2017-06-01
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